ChE Grad Seminar - Ting-Yu Shih, Ph.D., Assistant Professor, University of Rhode Island
Thursday, April 17, 2025 12:40 PM – Friday, April 18, 2025 1:45 AM
- LocationKirk Engineering Lab, Cherry Auditorium
- DescriptionImproving Cancer Immunotherapies and Targeted Therapies using Engineering Strategies
Abstract:
Immunotherapies and targeted therapies are emerging cancer treatments that have demonstrated unprecedented efficacy in subsets of cancer. However, expanded use of these novel therapies to treat other cancers is limited by life-threatening toxicity, resistance to therapy and/or costly manufacturing processes. I will discuss three projects where we utilized engineering strategies to address these issues. First, current cell-based cancer vaccines require costly ex vivo activation that often leads to short lifespan of the transplanted cells and rapid loss of their effector functions. We developed an injectable, pre-formed hydrogel-based cancer vaccine that recruits and modulates specific immune cells in situ and subsequently generates potent anti-tumor responses. I will also discuss a recent project developing self-amplifying RNA cancer vaccines that induce stronger and more durable immunity compared to conventional mRNA vaccines. Lastly, existing antibody-drug conjugates (ADCs) are limited by either heterogeneous drug conjugation at unspecific sites or instability and premature drug release in blood, causing off-target toxicity and reduced efficacy. We synthesized ADCs via supramolecular assembly of coiled coil peptides. This approach allows stable, uniform and site-specific drug conjugation and significantly simplifies ADC production with unprecedented modularity for optimization and development. - Websitehttps://events.uri.edu/event/che-grad-seminar-ting-yu-shih-phd-assistant-professor-university-of-rhode-island
- CategoriesLectures / Presentations, Virtual / Webinars